The Pathology of Poliomyelitis and the Vaccines and Nonvaccine Therapy

Poliomyelitis is an exclusively human disease that mainly affects children. Clinical features of poliomyelitis can be varied, from mild illness to the most severe paralysis, and factor why has different performances in individuals been proved strongly correlated with membrane protein CD155. The nervous system shows a special protecting phenomenon against invasion poliovirus, mechanism not very clear at present. Vaccines are main means preventing controlling polio, many vaccines have invented process fighting polio. Inactivated polio vaccine (IPV) oral (OPV) two vaccines. IPV known for its safety while OPV widely used developing countries because relatively low cost. This usage also leads some side effects: vaccine-associated paralytic (VAPP) vaccine-derived poliovirus (VDPV). Now, eradication, elimination these diseases become particularly important. Thus, new type was created: sequential IPV-OPV cost OPV. paper will talk about their effects. An enormous difference between people who gotten got vaccine. Comparing kinds people, get normal after taking vaccine, as VAPP (vaccine-associated poliomyelitis), former cannot full recovery whole life latter possibility. In conclusion, should take if it affordable them.